Ethylacetate fractional extract of Mentha spicata attenuates irinotecan‐induced mucositis in mice
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منابع مشابه
Protection against LPS-induced cartilage inflammation and degradation provided by a biological extract of Mentha spicata
BACKGROUND A variety of mint [Mentha spicata] has been bred which over-expresses Rosmarinic acid (RA) by approximately 20-fold. RA has demonstrated significant anti-inflammatory activity in vitro and in small rodents; thus it was hypothesized that this plant would demonstrate significant anti-inflammatory activity in vitro. The objectives of this study were: a) to develop an in vitro extraction...
متن کاملAcute Oral Toxicity and Brine Shrimp Lethality of Methanol Extract of Mentha Spicata L (Lamiaceae)
Purpose: To determine, in Sprague Dawley rats, the toxicity profile of the methanol extract of Mentha spicata, a plant used in folklore medicine for the treatment of various forms of pain. Methods: The plant extract, at concentrations ranging from 100 0.07 mg/ml, was used to determine the median lethal concentration (LC50) based on brine shrimp lethality assay. Artificial sea water served as co...
متن کاملPhenolic and Volatile Composition of a Dry Spearmint (Mentha spicata L.) Extract.
The present paper reports a complete mass spectrometric characterization of both the phenolic and volatile fractions of a dried spearmint extract. Phenolic compounds were analysed by ultra-high performance liquid chromatography-electrospray ionization-mass spectrometry (UHPLC-ESI-MS(n)) and a total of 66 compounds were tentatively identified, being the widest phenolic characterisation of spearm...
متن کاملAntinociceptive activity of Mentha piperita leaf aqueous extract in mice
BACKGROUND Mentha piperita L. (Labiatae) is an herbaceous plant, used in folk medicine for the treatment of several medical disorders. METHODS AND RESULTS In the present study, the aqueous extract of Mentha piperita leaf, at the i.p doses 200 and 400 mg/kg, showed significant analgesic effects against both acetic acid-induced writhing and hot plate-induced thermal stimulation in mice, with pr...
متن کاملAntiemetic activity of volatile oil from Mentha spicata and Mentha × piperita in chemotherapy-induced nausea and vomiting
BACKGROUND This study is aimed at determining the efficacy of Mentha spicata (M. spicata) and Mentha × piperita (M. × piperita) in preventing chemotherapy-induced nausea and vomiting (CINV). METHODS This was a randomised, double-blind clinical trial study. Prior to the study, patients were randomly assigned into four groups to receive M. spicata or M. × piperita. Statistical analysis included...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2019
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.2019.33.1_supplement.816.4